The Need of Wider and Deeper Skin Biopsy in Verrucous Carcinoma of the Sole
Article Sidebar
Main Article Content
Abstract
Verrucous carcinoma is a rare, slow-growing squamous cell carcinoma that can occur in acral regions, including the plantar surface, being named carcinoma cuniculatum. The tumor presents as a well-demarcated, exudative lesion, resembling benign conditions like warts or infections. In this case, a verrucous lesion on the left plantar surface initially appeared to be non-malignant, with multiple incisional biopsies showing only inflammation. A final excisional biopsy of a large part of it confirmed the initial suspicion of malignancy, prompting complete excision and appropriate management. This case underscores the importance of performing wide and deep biopsies for early diagnosis and timely treatment of a suspected verrucous carcinoma.
Article Details
Copyright (c) 2025 Damiani L, et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Saurat JH, LD, TL. Dermatology and Sexually Transmitted Infection. 6th ed. Paris: Edra; 2018.
Fawaz B, Vieira C, Decker A, Lawrence N. Surgical treatment of verrucous carcinoma: a review. J Dermatolog Treat. 2022;33(4):1811-1815. Available from: https://doi.org/10.1080/09546634.2021.1914312
Nagarajan D, Chandrasekhar M, Jebakumar J, Menon KA. Verrucous carcinoma of foot at an unusual site: lessons to be learnt. South Asian J Cancer. 2017;6(2):63. Available from: https://doi.org/10.4103/2278-330x.208839 DOI: https://doi.org/10.4103/2278-330X.208839
Chauhan K, Jassal V, Sara GK, Bansal V, Hatwal V. Histopathological study of verrucous lesions and its mimics. J Microsc Ultrastruct. 2021;9(2):86-97. Available from: https://doi.org/10.4103/jmau.jmau_47_19 DOI: https://doi.org/10.4103/JMAU.JMAU_47_19
Di Palma V, Stone JP, Schell A, Dawes JC. Mistaken diabetic ulcers: A case of bilateral foot verrucous carcinoma. Case Rep Dermatol Med. 2018;2018:4192657. Available from: https://doi.org/10.1155/2018/4192657 DOI: https://doi.org/10.1155/2018/4192657
Ye Q, Hu L, Jia M, Deng LJ, Fang S. Cutaneous verrucous carcinoma: a clinicopathological study of 21 cases with long-term clinical follow-up. Front Oncol. 2022;12:953932. Available from: https://doi.org/10.3389/fonc.2022.953932 DOI: https://doi.org/10.3389/fonc.2022.953932
Farag AF, Abou-Alnour DA, Abu-Taleb NS. Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: a systematic review. Imaging Sci Dent. 2018;48(4):233-244. Available from: https://doi.org/10.5624/isd.2018.48.4.233 DOI: https://doi.org/10.5624/isd.2018.48.4.233
Shwe Daniel S, Cox SV, Kraus CN, Elsensohn AN. Epithelioma cuniculatum (plantar verrucous carcinoma): a systematic review of treatment options. Cutis. 2023;111(2):E19-E24. Available from: https://doi.org/10.12788/cutis.0720 DOI: https://doi.org/10.12788/cutis.0720
Fawaz B, Vieira C, Decker A, Lawrence N. Surgical treatment of verrucous carcinoma: a review. J Dermatolog Treat. 2022;33(4):1811-1815. Available from: https://doi.org/10.1080/09546634.2021.1914312 DOI: https://doi.org/10.1080/09546634.2021.1914312
Nunes-Abreu F, Hidalgo-Caro R, Lorda-Barraguer E, Cristóbal-Redondo V, Céspedes-Guirao FJ. Consider carcinoma cuniculatum in recurrent foot ulcer: a case report and literature review. Arch Plast Surg. 2024;51(6):575-580. Available from: https://doi.org/10.1055/a-2316-3824 DOI: https://doi.org/10.1055/a-2316-3824