Abstract

Review Article

The coral crunch: Amyloidoma

Anubha Bajaj*

Published: 20 January, 2021 | Volume 5 - Issue 1 | Pages: 001-005

Amyloidoma is an exceptional, progressive disorder demonstrating a characteristic accumulation of significant quantities of amyloid within soft tissues. Amyloidoma is additionally nomenclated as tumoural amyloidosis, nodular amyloid or localized amyloidosis. Furthermore, insulin-derived amyloidoma is referred to as insulin ball. Amyloid is a protein polymer configured of identical monomeric protein units wherein pathological variety is articulated from misfolded proteins. In excess > of twenty three subtypes of proteins can configure amyloid fibres in vivo. Extra-cellular or intra-cellular deposition of amyloid can modify normal organ function [1].

Amyloidosis is categorized into systemic and localized subtypes. Localized amyloidosis displays a localized mass effect and demonstrates a superior prognosis. Insulin-derived amyloidosis was initially documented by Storkel, et al. in 1983 who recognized accumulated insulin- amyloid fibrils in diabetic individuals subjected to continuous infusion of porcine insulin over a period of 5 weeks or more [1,2]. Amyloid nodules may be associated with systemic amyloidosis.

Read Full Article HTML DOI: 10.29328/journal.adr.1001013 Cite this Article Read Full Article PDF

Keywords:

Antisecretory function; Cross-reactivity; Delayed reaction; Famotidine; Hypersensitivity; Maculopapular exanthema; Patch test; Ranitidine

References

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